Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality
T Dunlap, SO Abdul-Hay, REP Chandrasena… - Nitric Oxide, 2008 - Elsevier
Properties of the NO-ASA family of NO-donating NSAIDs (NO-NSAIDs), notably NCX 4016
(mNO-ASA) and NCX 4040 (pNO-ASA), reported in more than one hundred publications,
have included positive preclinical data in cancer chemoprevention and therapy. Evidence is
presented that the antiproliferative, the chemopreventive (antioxidant/electrophile response
element (ARE) activation), and the anti-inflammatory activity of NO-ASA in cell cultures is
replicated by X-ASA derivatives that are incapable of acting as NO donors. pBr-ASA and …
(mNO-ASA) and NCX 4040 (pNO-ASA), reported in more than one hundred publications,
have included positive preclinical data in cancer chemoprevention and therapy. Evidence is
presented that the antiproliferative, the chemopreventive (antioxidant/electrophile response
element (ARE) activation), and the anti-inflammatory activity of NO-ASA in cell cultures is
replicated by X-ASA derivatives that are incapable of acting as NO donors. pBr-ASA and …
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